Is Calorie Restriction worth prioritizing?

Caloric restriction (CR) is one of the most robust life-extension interventions in animal biology, but direct human lifespan evidence does not exist and probably never will via RCT. Weighing that against the numbers, Calorie Restriction is not a priority based on current data — the evidence is only moderate (45/100), and its estimated impact (45/100) is on the lower end too.