Is Calorie Restriction good for longevity?

The evidence points that way, though it's not yet conclusive. Caloric restriction (CR) is one of the most robust life-extension interventions in animal biology, but direct human lifespan evidence does not exist and probably never will via RCT. That's reflected in an evidence score of 45/100 for its role in longevity, drawn from 9 studies (4 RCTs), with an estimated impact on longevity rated moderate (45/100).