Does Calorie Restriction actually make a difference, or is it overhyped?

Caloric restriction (CR) is one of the most robust life-extension interventions in animal biology, but direct human lifespan evidence does not exist and probably never will via RCT. Weighing the data: Calorie Restriction looks an early-stage, lower-priority area for now — the evidence is only moderate (45/100), and its estimated impact (45/100) is on the lower end too.