Vitaebase

How many studies support Calorie Restriction?

Caloric restriction (CR) is one of the most robust life-extension interventions in animal biology, but direct human lifespan evidence does not exist and probably never will via RCT. That's backed by 9 published studies in Vitaebase's database, including 4 randomized controlled trials, the most recent from 2025 -- a fairly substantial body of research for a single topic.

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Calorie Restriction

Moderate evidence

Evidence

45

Impact

45

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Key studies behind this answer

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.Randomized Controlled Trial · Nature aging · 2023Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.Randomized Controlled Trial · Nutrition reviews · 20212 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.Randomized Controlled Trial · The lancet. Diabetes & endocrinology · 2019

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