Is Folate worth prioritizing?

Folate's best-established benefit is preventing neural tube defects: a Cochrane review and multiple systematic reviews consistently support periconceptional folic acid supplementation for this purpose, one of the more unambiguous wins in preventive nutrition. Weighing that against the numbers, Folate is a strong candidate to prioritize — it combines strong evidence (77/100) with a high estimated impact on longevity (60/100).