How many studies support Folate?

Folate's best-established benefit is preventing neural tube defects: a Cochrane review and multiple systematic reviews consistently support periconceptional folic acid supplementation for this purpose, one of the more unambiguous wins in preventive nutrition. That's backed by 9 published studies in Vitaebase's database, including 9 meta-analyses, the most recent from 2025 -- a fairly substantial body of research for a single topic.