Does Folate actually make a difference, or is it overhyped?

Folate's best-established benefit is preventing neural tube defects: a Cochrane review and multiple systematic reviews consistently support periconceptional folic acid supplementation for this purpose, one of the more unambiguous wins in preventive nutrition. Weighing the data: Folate looks well-supported and consequential — the evidence is rated strong (77/100) and its estimated impact on longevity is also rated highly (60/100), making it one of the more solidly-backed choices on Vitaebase.