Association of Optimism with Cardiovascular Events and All-Cause Mortality: Systematic Review and Meta-Analysis.

Krittanawong C, Maitra NS, Hassan Virk HU, Fogg S, Wang Z, Kaplin S, Gritsch D, Storch EA, Tobler PN, Charney DS, Levine GN

The American journal of medicine · July 1, 2022

Meta-Analysis

Background: The effect of psychological health on cardiovascular disease is an underappreciated yet important area of study. Method: A systematic search of electronic databases was conducted from inception through November 2021 for prospective studies evaluating optimism and adverse outcomes. Pooled hazard ratios were calculated in random-effects meta-analyses. Results: Pooled analysis of six studies (n = 181,709) showed a pooled hazard ratio of 0.87 (95% CI, 0.82-0.92) for all-cause mortality among those with more optimistic mindset. Analysis of seven studies (n = 201,210) showed a pooled hazard ratio of 0.59 (95% CI, 0.37-0.93) for cardiovascular disease. Conclusions: In this pooled meta-analysis, optimism was associated with a reduced risk of all-cause mortality and of cardiovascular disease.

PMID: 35123934 · DOI: 10.1016/j.amjmed.2021.12.023

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Association of Optimism with Cardiovascular Events and All-Cause Mortality: Systematic Review and Meta-Analysis.

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