Is Coenzyme Q10 worth prioritizing?

Meta-analyses spanning from 1997 through a 2014 Cochrane review find CoQ10 supplementation can modestly improve symptoms and some outcomes in heart failure, though a 2022 health-technology assessment concluded the evidence is not yet strong enough to firmly establish cost-effective clinical benefit for reduced-ejection-fraction heart failure specifically. Weighing that against the numbers, Coenzyme Q10 is not a priority based on current data — the evidence is only moderate (58/100), and its estimated impact (30/100) is on the lower end too.