Is Circadian Rhythm worth prioritizing?

Shift work is the best human model for studying real-world circadian disruption, and the evidence here is unusually consistent: two independent dose-response meta-analyses find shift work increases cardiovascular disease morbidity and mortality, and a more recent meta-analysis of night shift work specifically confirms elevated cardiovascular risk indicators. Weighing that against the numbers, Circadian Rhythm is a strong candidate to prioritize — it combines strong evidence (72/100) with a high estimated impact on longevity (60/100).