Does Circadian Rhythm actually make a difference, or is it overhyped?

Shift work is the best human model for studying real-world circadian disruption, and the evidence here is unusually consistent: two independent dose-response meta-analyses find shift work increases cardiovascular disease morbidity and mortality, and a more recent meta-analysis of night shift work specifically confirms elevated cardiovascular risk indicators. Weighing the data: Circadian Rhythm looks well-supported and consequential — the evidence is rated strong (72/100) and its estimated impact on longevity is also rated highly (60/100), making it one of the more solidly-backed choices on Vitaebase.