Does Curcumin actually make a difference, or is it overhyped?

A GRADE-assessed dose-response meta-analysis found curcumin supplementation reduces inflammatory and oxidative stress markers, an effect replicated across specific populations including people with chronic inflammatory diseases, metabolic syndrome, non-alcoholic fatty liver disease, and chronic kidney disease. Weighing the data: Curcumin looks an early-stage, lower-priority area for now — the evidence is only moderate (58/100), and its estimated impact (40/100) is on the lower end too.