How strong is the evidence for Cognitive Health?

This topic has unusually strong randomized-trial evidence for a behavioral field: the landmark FINGER trial (Lancet, 2015) showed a 2-year multidomain intervention combining diet, exercise, cognitive training and vascular risk management improved cognitive function in at-risk older adults, with benefit holding regardless of baseline characteristics, and this has now been extended by the large US POINTER randomized trial (JAMA, 2025) comparing structured and self-guided versions of the same approach. That evidence is currently rated strong (87/100), built on 11 published studies, including 3 randomized controlled trials and 4 meta-analyses -- enough for real confidence in the effect.