Does Omega-3 actually make a difference, or is it overhyped?

The cardiovascular evidence for omega-3 supplementation is a useful case study in scientific nuance: a Cochrane review found little to no clear benefit for primary or secondary cardiovascular disease prevention, while a separate, larger meta-analysis of 13 randomized trials covering over 127,000 participants and dose-response analyses found modest but real reductions in cardiovascular events — the two conclusions differ mainly by which trials and doses are emphasized. Weighing the data: Omega-3 looks an early-stage, lower-priority area for now — the evidence is only moderate (55/100), and its estimated impact (35/100) is on the lower end too.